It's 1939, in New York City. Joe Kavalier, a young artist who has also been trained in the art of Houdiniesque escape, has just pulled off his greatest feat: smuggling himself out of Hitler's Prague. He's looking to make big money, fast, so that he can bring his family to freedom. His cousin, Brooklyn's own Sammy Clay, is looking for a partner in creating the heroes, stories, and art for the latest novelty to hit the American dreamscape: the comic book.

Inspired by their own fantasies, fears, and dreams, Kavalier and Clay create the Escapist, the Monitor, and the otherworldly Mistress of the Night, Luna Moth, inspired by the beautiful Rosa Saks, who will become linked by powerful ties to both men. The golden age of comic books has begun, even as the shadow of Hitler falls across Europe.